Artículos Originales ::: Original Papers
(desde/ since 2001 hasta/ to 2006)


Cacabelos, R. Psychogeriatric research: A conceptual introduction to aging and geriatric neuroscience. Psychogeriatrics, 1:158-188 (2001).

Allison, A.C., Cacabelos, R., Lombardi, V.R.M., Alvarez, X.A., Vigo, C. Celastrol, a potent antioxidant and anti-inflammatory drug, as a posible treatment for Alzheimer’s disease. Prog. Neuro-Psychopharmacol. Biol. Psychiat., 25:1341-1357 (2001).

Cacabelos, R., Santamaría, J.L. Hipertensión y Demencia. Mecanismos etiopatogénicos y factores genéticos. Hipertensión Clínica, IV/3:626-659 (2001).

Fernández-Novoa, L., Cacabelos, R. Histamine function in brain disorders. Behav. Brain Res., 124:213-233 (2001).

Cacabelos, R. Enfermedad de Alzheimer. Presente terapéutico y retos futuros (I). Rev. Colomb. Psiquiatría, XXX/3:215-238 (2001).

Cacabelos, R. Enfermedad de Alzheimer. Presente terapéutico y retos futuros (II). Rev. Colomb. Psiquiatría, XXX/4:323-350 (2001).

Lombardi, V.R.M., Cagiao, A., Fernández-Novoa, L., Alvarez, X.A., Corzo, L., Zas, R., Sampedro, C., Cacabelos, R. Short term food supplementation effects of a fish derived extract on the immunological status of pregnant rats and their sucking pups. Nutrition Res., 21:1425-1434 (2001).

Cacabelos, R. Pharmacogenomics in Alzheimer´s disease. Min. Rev. Medic. Chem.,.2:59-84 (2002).
Cacabelos, R. Pharmacogenomics for the treatment of dementia. Ann. Med., 34:357- 379 (2002).

Lombardi, V.R.M., Fernández-Novoa, L., Corzo, D., Zas, R., Cacabelos, R. Enhancement in immune function and growth using E-JUR-94013 supplementation. Meth. Find. Exp. Clin. Pharmacol., 24:573-578 (2002).

Miguel-Hidalgo, J.J., Alvarez, X.A., Cacabelos, R., Quack, G. Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40). Brain Res., 958:210-221 (2002).

Cacabelos, R. The histamine-citokine network in Alzheimer disease: Etiopathogenic and pharmacogenomic implications. En: Mapping the Progress of Alzheimer’s and Parkinson’s Disease. Y. Mizuno, A. Fisher, I. Hanin, Eds. Advances in Behavioral Biology, Vol., 51:59-64 (2002).

Takeda, M., Cacabelos, R., Ray, O., Förstl, H., Hoon Oh, B. International perspective on the diagnosis and treatment of dementia. Cognition & Dementia, 2:53-63 (2003).

Takeda, M., Okochi, M., Sugaya, K., De-Maw, C., Hashimoto, R., Kuroda, S., Shinosaka, K., Kudo, T., Tanaka, T., Cacabelos, R. Research strategy for understanding neuronal plasticity and degeneration. Seishin Shinkeigaku Zasshi, 105:43-46 (2003).

Cacabelos, R., Fernández-Novoa, L., Lombardi, V., Takeda, M. Genetic variation and pharmacogenomics in Alzheimer disease. Psychiat. Neurol. Jap., 105:47-67 (2003).

Lombardi, V.R.M., Etcheverría, I., Fernández-Novoa, L., Cacabelos, R. In vitro regulation of rat derived microglia. Neurotox. Res., 5:201-212 (2003).

Lombardi, V.R.M., Etcheverría, I., Fernández-Novoa, L., Blanco, A., Díaz, J., Cacabelos, R. Extracts from Polypodium ferns upregulate the expresión of CD95 in human peripheral blood lymphocytes. Orient. Pharm. Exper. Med., 3:90-99 (2003).

Alvarez, X.A., Sampedro, C., Pérez, P., Laredo, M., Couceiro, V., Hernández, A., Figueroa, J., Varela, M., Arias, D., Corzo, L., Zas, R., Lombardi, V., Fernández-Novoa, L., Pichel, V., Cacabelos, R., Windisch, M., Aleixandre, M., Moessler, H. Positive effects of cerebrolysin on electroencephalogram slowing, cognition and clinical outcome in patients with postacute traumatic brain injury: an exploratory study. Intern. Clin. Psychopharmacol., 18:271-278 (2003).

Cacabelos, R. The application of functional genomics to Alzheimer’s disease. Pharmacogenomics, 4:597-621 (2003).

Isaza, C., Henao, J., López, A.M., Cacabelos, R. Allelic variants of the thiopurine methyltransferase (TPMT) gene in the Colombian population. Meth. Find. Exp. Clin. Pharmacol., 25:423-429 (2003).

Cacabelos, R., Fernández-Novoa, L., Lombardi, V., Corzo, L., Pichel, V., Kubota, Y.Cerebrovascular risk factors in Alzheimer’s disease: Brain hemodynamics and pharmacogenomic implications. Neurol. Res., 25:567-580 (2003).

Lombardi, V.R.M., Fernández-Novoa, L., Cacabelos, R. Neuroglia and neurotrophic factors (NTFs): potencial targets for future therapeutics. Current Topics in Pharmacology, 7(2):229-246 (2003).

Pichel, V., Etcheverría, I., Amado, L., Kubota, Y., Cacabelos, R. Cerebrovascular risk factors and brain hemodynamics in dementia. In: Hanin, I., Fisher, A., Cacabelos, R. (Eds). New Trends in Alzheimer- and Parkinson-Related Disorders. Monduzzi Editore, Bologna, pp. 23-27 (2003).

Lombardi, V.R.M., Amado, L., Fernández-Novoa, L., Etcheverría, I., Seoane, S., Cacabelos, R. Flow cytometry análisis of CD28-/CD8+ supresor cell precursor and CD45RO+/CD4+ memory T lymphocytes in the peripheral blood of Alzheimer’s disease patients. In: Hanin, I., Fisher, A., Cacabelos, R. (Eds). New Trends in Alzheimer- and Parkinson-Related Disorders. Monduzzi Editore, Bologna, pp. 57-61 (2003).

Corzo, L., Zas, R., Fernández-Novoa, L., Cacabelos, R. FERUM nitric oxide in Alzheimer disease. In: Hanin, I., Fisher, A., Cacabelos, R. (Eds). New Trends in Alzheimer- and Parkinson-Related Disorders. Monduzzi Editore, Bologna, pp. 63-68 (2003).

Kubota, Y., Pichel, V., Fernández-Novoa, L., Cacabelos, R. Combination therapy in Alzheimer disease: a pharmacogenomic study. In: Hanin, I., Fisher, A., Cacabelos, R. (Eds). New Trends in Alzheimer- and Parkinson-Related Disorders. Monduzzi Editore, Bologna, pp. 87-90 (2003).

Etcheverría, I., Pichel, V., Amado, L., Fernández-Novoa, L., Lombardi, V., Cacabelos, R.  APOE genotype-related brain atrophy in the Spanish population. In: Hanin, I., Fisher, A., Cacabelos, R. (Eds). New Trends in Alzheimer- and Parkinson-Related Disorders. Monduzzi Editore, Bologna, pp. 91-96 (2003).

Fernández-Novoa, L., Lombardi, V.R.M., Seoane, S., Etcheverría, I., Corzo, L., Cacabelos, R. The ACE gene in Alzheimer’s disease. In: Hanin, I., Fisher, A., Cacabelos, R. (Eds). New Trends in Alzheimer- and Parkinson-Related Disorders. Monduzzi Editore, Bologna, pp. 123-126 (2003). 

Lombardi, V.R.M., Fernández-Novoa, L., Etcheverría, I., Seoane, S., Cacabelos, R. Association between APOE-4 allele and increased expresión of CD95 on T cells from patients with Alzheimer’s disease. Meth. Find. Exp. Clin. Pharmacol., 26(7): 523-529 (2004).

Cacabelos, R., Corzo, L., Fernández-Novoa, L., Lombarda, V. Histamine in Alzheimer’s disease patogénesis: Biochemistry and functional genomics. Meth. Find. Exp. Clin. Pharmacol., 26(Suppl. 2): 9-16 (2004).

Cacabelos, R., Vallejo, A.I., Lombardi, V., Fernández-Novoa, L., Pichel, V. E-SAR-94010 (LipoEsar®): A pleiotropic lipoprotein compound with powerful anti-atheromatous and lipid lowering effects. CNS Drug Rev., 10(2): 200-201 (2004).

Cacabelos, R., Fernández-Novoa, L., Corzo, L., Pichel, V., Lombardi, V., Kubota, Y. Genomics and phenotypic profiles in dementia: Implications for pharmacological treatment. Meth. Find. Exp. Clin. Pharmacol., 26(6): 421-444 (2004).

Cacabelos, R., Fernández-Novoa, L., Corzo, L., Amado, L., Pichel, V., Lombardi, V., Kubota, Y. Phenotypic profiles and functional genomics in Alzheimer’s disease and in dementia with a vascular component. Neurol. Res., 26: 459-480 (2004).

Cacabelos, R. Genomic characterization of Alzheimer’s disease and genotype-related phenotypic analysis of biological markers in dementia. Pharmacogenomics 5(8):1049-1105 (2004).

Cacabelos, R., Fernández-Novoa, L., Pichel, V., Lombardi, V., Kubota, Y., Takeda, M. Pharmacogenomic studies with a combination therapy in Alzheimer’s disease. In: Molecular Neurobiology of Alzheimer’s Disease and Related Disorders. Takeda, M., Tanaka, T., Cacabelos, R. (Eds). Karger, Basel, pp. 94-107 (2004).

Cacabelos, R., Lombarda, V., Fernández-Novoa, L., Kubota, Y., Corzo, L., Pichel, V., Takeda, M. A functional genomics approach to the analysis of biological markers in Alzheimer disease. In: Molecular Neurobiology of Alzheimer’s Disease and Related Disorders. Takeda, M., Tanaka, T., Cacabelos, R. (Eds). Karger, Basel, pp. 236-285 (2004).

Isaza, C., Henao, J., Ramírez, E., Cuesta, F., Cacabelos, R. Polymorphic variants of the beta-2-adrenergic receptor (ADRB2) gene and ADRB2-related propanolol-induced dyslipidemia in the Colombian population. Meth. Find. Exp. Clin. Pharmacol., 27(4): 237-244 (2005).

Cacabelos, R. Función cerebrovascular en la enfermedad de Alzheimer (2005) www.sinapsis.org/

Lombardi, V.R.M., Fernández-Novoa, L., Etcheverría, I., Seoane, S., Cacabelos, R. Effects of fish-derived lipoprotein extracts on activation markers, Fas expresión and apoptosis in peripheral blood lymphocytes. Intern. Immunopharmacol., 5: 253-262 (2005).

Cacabelos, R., Kubota, Y., Isaza, C., Henao, J., Fernández-Novoa, L., Lombarda, V.R.M., Corzo, L., Pichel, V. Functional genomics and pharmacogenetics in Alzheimer’s disease. In: Recent Progress in Alzheimer’s and Parkinson’s Diseases. Hanin, I., Cacabelos, R., Fisher, A. (Eds). Taylor & Francis, London, pp. 89-102 (2005).

Lombardi, V.R.M., Fernández-Novoa, L., Etcheverría, I., Seoane, S., Cacabelos, R. Regulating factors for microglial activation: implication for Alzheimer’s disease and brain damage.  . In: Recent Progress in Alzheimer’s and Parkinson’s Diseases. Hanin, I., Cacabelos, R., Fisher, A. (Eds). Taylor & Francis, London, pp. 171-176 (2005).

Cacabelos, R., Fernández-Novoa, L., Lombardi, V., Kubota, Y., Takeda, M. Molecular genetics of Alzheimer’s disease and aging. Meth. Find. Exp. Clin. Pharmacol., 27(Suppl. A): 1-573 (2005).

Cacabelos, R. Pharmacogenomics, nutrigenomics and therapeutic optimization in Alzheimer’s disease. Aging Health 1(2): 303-348 (2005).

Cacabelos, R. Pharmacogenomics and therapeutic prospects in Alzheimer’s disease. Expert Opin. Pharmacother. 6(12): 1967-1987 (2005).

Cacabelos, R. Role of nutrition in the prevention of Alzheimer’s disease. Aging Health 1(3): 359-362 (2005).

Alvarez, X.A., Corzo, L., Laredo, M., Sampedro, C., Cacabelos, R., Windisch, M., Moessler, H., Crook, T.H. Neuropeptide dietary supplement N-PEP-12 enhances cognitive function and activates brain bioelectrical activity in healthy elderly subjects. Meth. Find. Exper. Clin. Pharmacol., 27(7): 493-487 (2005).

Cacabelos, R. Homocysteine and cognition: from Galenic dogmatism to genetic relativism. Aging Health, 2(5):783-786 (2006).

Alvarez, X.A., Cacabelos, R., Laredo, M., Cruceiro, V., Sanpedro, C., Varela, M., Corzo, L., Fernández-Novoa, L., Vargas, M., Aleixandre, M., Linares, C., Granizo, E., Muresanu, D., Moessler, H. A 24-week, double-blind, placebo-controlled study of three dosages of Cerebrolysin in patients with mild to moderate Alzheimer’s disease. Eur. J. Neurol., 13:43-54 (2006).

Cacabelos, R., Takeda, M. Pharmacogenomics, nutrigenomics and future therapeutics in Alzheimer’s disease. Drugs Future, 31(Suppl. B):5-146 (2006).